The Demons have also included Rohan Bail, Matthew Bate and Daniel Nicholson into their 22-man squad.
Fitzpatrick is in contention to play his first AFL match, after he was named in the initial squad last round.
The key forward/ruckman kicked four goals for Casey last round.
The quartet has been named on the extended interchange, along with Tom McNamara, Luke Tapscott and Jeremy Howe.
As expected, forward Liam Jurrah is out of the side with a wrist injury, sustained against Gold Coast Suns last round.
Versatile tall Stef Martin will play his 50th AFL match.
It will be the first time an AFL match will be staged at the better known international cricket venue.
Melbourne
B: Sam Blease, James Frawley, Tom McDonald
HB: Colin Garland, Jared Rivers, Clint Bartram
C: Nathan Jones, Jordie McKenzie, Jamie Bennell
HF: Brad Green, Jack Watts, Jack Trengove
F: Tom Scully, Stef Martin, Neville Jetta
FOLL: Mark Jamar, Cale Morton, Brent Moloney
I/C (from): Matthew Bate, Tom McNamara, Luke Tapscott, Jeremy Howe, Rohan Bail, Jack Fitzpatrick, Daniel Nicholson
IN: Rohan Bail, Matthew Bate, Jack Fitzpatrick, Daniel Nicholson
OUT: Liam Jurrah (wrist)
NEW: Jack Fitzpatrick