McDonald suffered a hamstring injury against Carlton in round 11 and missed the Queen’s Birthday draw against Collingwood.
The 33-year-old has been one of Melbourne’s best performers this year, recapturing the type of form that netted him back-to-back Keith ‘Bluey’ Truscott Memorial Trophies in 2006/07.
McDonald has played 246 matches and is only four matches away from becoming the seventh player to play 250 matches or more for Melbourne.
Young Demons Luke Tapscott (hip) and Sam Blease (leg), who have yet to play this season, are now only one week away from resuming with Casey Scorpions.
Rookie list players Danny Hughes (ankle) and Michael Newton (calf) will spend another week on the sidelines.
First-year ruckman Max Gawn is still three to four weeks away from resuming.
Ricky Petterd (shoulder) and John Meesen (ankle) remain sidelined long-term.
Round 13 injury list