The Demons are already missing Tom Scully (knee), Jordie McKenzie (groin), Mark Jamar (knee), Jack Grimes (foot), Jared Rivers (ankle) and Jack Trengove (suspension) from their best 22.
Garland was subbed out at the four-minute mark of the third quarter in Saturday’s 41-point loss to North Melbourne after losing the battle with the ankle he injured earlier on.
Bail was helped from the field 10 minutes later after injuring his left knee, which coach Dean Bailey said looked to be to his posterior cruciate ligament - the same complaint set to sideline Jamar for four to six weeks.
"Garlo, we're not sure. He did an ankle and came back on. He was hobbling around there but he could put weight on his ankle before," Bailey said after the match.
"He's probably 24-48 hours but I'd probably be saying it doesn't look too good at this stage. With an ankle you have to wait and see."
Both players were on crutches in the rooms following the Etihad Stadium clash.
Bailey said the two players were the only ones to have sustained serious injuries on Saturday outside of "normal bumps and bruises" but conceded the clubs' depth was poised to be tested in coming weeks with matches against St Kilda, Carlton, Essendon and Collingwood on the cards.
"We've got some guys that have been playing with good form in the VFL, and I'll go and watch them tomorrow and see who plays well," he said.
"It's going to be important for them to perform well and still perform well knowing there's going to be a couple of spots available next week.
"It doesn't mean there's only going to be two. We've got to evaluate the game and make sure the guys who play next week are certainly playing better as a team than we did today."
Bailey said he was unsure if any of the players from the Demons' best 22 would be available to come in for next Saturday's clash with the Saints at Etihad Stadium.
He said the loss of Garland and Bail didn't help the Demons' cause against the Kangaroos but was more concerned with why his players failed to hit targets or win turnovers from tackles.
Bailey blamed skill execution and decision making for his side's dramatic fade out that saw them forfeit a 31-point first quarter lead.
He also said he wouldn't blame the past week's off-field incidents involving Jack Trengove's three-match suspension and subsequent appeal, and the financial sanctions handed to Ricky Petterd and James Frawley for their criticism of the tribunal's decision.
"They're professional footballers so once the siren goes and the umpire's bounced the ball, you're into the game; you're not into anything else," he said.
"I don't think it was a distraction, to say that it was the reason we didn't play well [isn’t true].
"It was a different game from last week where we were able to contribute for four quarters. This week, we only contributed for one and bit and pieces of the next three.
"That was probably the disappointing thing; coming into this game on the back of some good form last week. We should have really put on a better performance today."
